HMG 75 IU
99%+ Purity Guaranteed
Research Use Only
Secure Checkout

HMG 75 IU

SKU:  HMG75IU

HMG 75 IU
1
Price range: $37.95 through $379.50
Check Lab Report
Same Trusted Formula. Fresh New Look.During our packaging transition, you may receive products with either our previous or updated label. Rest assured, the formulation, purity and quality remain exactly the same as per our standards.
Accepted Payment MethodsYour data is protected with 256-bit encryption.Accepted payment methods

Human Menopausal Gonadotropin (HMG) is a gonadotropin preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. These glycoprotein hormones interact with their respective receptors, follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR), both of which belong to the G protein-coupled receptor (GPCR) superfamily. Activation of these receptors initiates Gsα-coupled signaling pathways, resulting in intracellular cAMP generation, protein kinase A (PKA) activation, and downstream signal transduction processes.

Experimental investigations have utilized HMG as a research tool for studying gonadotropin receptor pharmacology, receptor-ligand interactions, GPCR signaling mechanisms, receptor activation kinetics, and comparative analyses of FSHR and LHCGR-mediated pathways. Research applications include gonadotropin signaling studies, receptor characterization, signal transduction investigations, and mechanistic evaluation of glycoprotein hormone receptor biology.

  • High Purity — 99%+ Purity Guaranteed
  • Independently Lab Tested
  • Research Grade Quality
  • For Laboratory Research Use Only
All SwissChems products are independently third-party tested at a USA-based HPLC-licensed laboratory prior to distribution. Certificates of Analysis (COA) are published on the Independent Test Results page and available at product level. If any independently conducted HPLC test returns a negative result, SwissChems will refund: (1) the cost of the HPLC test, and (2) the full order amount including shipping.
Chemical FormulaN/A
Synonyms6,6-dimethylheptanal, Human Menopausal Gonadotrophin, Menotrophin, gonadotropin from human menopausal urine
Molar Mass142.24 g/mol
CAS Number61489-71-2
PubChem CIDN/A
Total Compound Content75 IU per vial
Shelf Life36 months
HMG (Human Menopausal Gonadotropin) is a gonadotropin preparation standardized for both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivity, typically providing a balanced ratio of FSH and LH activity. The FSH component interacts with follicle-stimulating hormone receptor (FSHR), while the LH component interacts with luteinizing hormone/choriogonadotropin receptor (LHCGR), both members of the G protein-coupled receptor (GPCR) superfamily. Activation of these receptors initiates Gsα-coupled signaling pathways, resulting in intracellular cAMP generation, protein kinase A (PKA) activation, and downstream signal transduction processes associated with gonadotropin receptor signaling. As a biologically sourced glycoprotein preparation, HMG contains multiple glycoforms exhibiting varying degrees of glycosylation and sialylation. This molecular heterogeneity distinguishes HMG from recombinant single-hormone preparations and has made it a useful research tool for investigating glycoprotein hormone structure-function relationships, receptor-ligand interactions, receptor activation kinetics, and the influence of glycosylation patterns on GPCR signaling dynamics. Research applications include gonadotropin receptor pharmacology, FSHR and LHCGR signaling studies, glycoprotein hormone characterization, and mechanistic evaluation of receptor-mediated signal transduction. HMG 75 IU per vial. Independently third-party HPLC-tested; COA available per batch.
What is the significance of combined FSH and LH activity in HMG research?

HMG contains both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivity, enabling simultaneous investigation of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR) signaling pathways. This combined receptor activity makes HMG a useful research tool for studying gonadotropin receptor pharmacology, receptor-ligand interactions, comparative GPCR signaling mechanisms, and the relationship between FSHR- and LHCGR-mediated signal transduction processes.

How does HMG differ from recombinant gonadotropin preparations?

HMG contains multiple glycoprotein hormone isoforms exhibiting varying degrees of glycosylation and sialylation, whereas recombinant preparations are generally characterized by more defined glycoform profiles. This molecular heterogeneity has made HMG valuable for investigations examining glycoprotein hormone structure-function relationships, receptor binding characteristics, glycoform-dependent signaling behavior, and the influence of glycosylation patterns on receptor activation kinetics.

What signaling pathways are activated by FSHR and LHCGR?

FSHR and LHCGR are members of the G protein-coupled receptor (GPCR) superfamily that primarily signal through Gsα-mediated activation of adenylyl cyclase, resulting in intracellular cAMP generation and protein kinase A (PKA) activation. These receptors are widely utilized in research examining GPCR signaling dynamics, receptor activation mechanisms, second-messenger systems, receptor-ligand interactions, and downstream signal transduction pathways associated with glycoprotein hormone receptor biology.

You May Also Like

View All Products →