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P21 5mg
SKU: P21-5MG-5K
NOTE: In some cases wherein the assigned top colors are out of stock, a different top color will be used to ensure that your order will not be delayed.Peptides are stable at room temperature and can be stored in their original packaging for several days to weeks. For longer storage, keep them at 4 °C or colder, away from intense light. Do not shake peptides before or after reconstitution, refrigerate them, and handle with care.
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Contact Us →P21 (Peptide 021) is a synthetic tetrapeptide derived from a fragment of ciliary neurotrophic factor (CNTF), developed for experimental studies on neurotrophic signalling. Research interest centers on its proposed role in supporting neurogenesis and synaptic function research models, with structural modifications studied for their effect on compound stability and blood-brain barrier permeability characteristics. Research applications include CNTF pathway studies, neurotrophic peptide structure-activity research, and synaptic function investigation.
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3D Molecular Structure of C27H42N6O8
CarbonHydrogenFluorineNitrogenOxygenSulfur
| Chemical Formula | C27H42N6O8 |
|---|---|
| Synonyms | P021, Ac-dggl-adamatanylglycine-NH2, P-21 nootropic peptide |
| Molar Mass | 578.7 g/mol |
| CAS Number | 1246751-68-7 |
| PubChem CID | 56599151 |
| Total Compound Content | 5mg per vial |
| Shelf Life | 36 months |
P21 (Peptide 021) is a synthetic tetrapeptide derived from a fragment sequence of ciliary neurotrophic factor (CNTF), engineered for experimental studies on neurotrophic signalling pathways. Research models examine its proposed contribution to neurogenesis-related and synaptic function endpoints, with particular research interest in the structural modifications incorporated into the peptide sequence and their proposed influence on proteolytic stability and blood-brain barrier permeability relative to the native CNTF fragment. As a CNTF-derived research tool, P21 is studied within the broader neurotrophic factor signalling research framework alongside other CNTF and related cytokine receptor pathway investigations. Independently third-party HPLC-tested; COA available per batch.
No lab reports have been added yet.
What is the relationship between P21 and the parent CNTF protein in neurotrophic signalling research?
P21 is a synthetic peptide derived from a fragment of ciliary neurotrophic factor (CNTF), a signalling protein involved in neuronal growth, differentiation, and survival pathways. Research with P21 focuses on determining whether this smaller peptide fragment can reproduce selected downstream signalling effects associated with CNTF while providing a simplified tool for studying neurotrophic pathway regulation.
What structural modifications were incorporated into P21's design?
P21 incorporates modifications to the native CNTF-derived fragment that have been investigated for their effects on peptide stability and tissue distribution. Comparative structure-activity studies examine how these modifications influence degradation resistance, signalling activity, and overall experimental utility relative to unmodified peptide fragments.
What experimental endpoints are used to study P21's proposed effects on neurogenesis and synaptic function?
Research commonly utilizes neural cell culture systems to evaluate neurogenesis-associated biomarkers, neuronal differentiation markers, synaptic protein expression, and signalling pathways related to neuronal plasticity. Additional endpoints may include measurements of neurite outgrowth, cellular maturation, and electrophysiological markers of synaptic activity to characterize effects on neural network function.
